HCID 67467267, compound → HCID 67462180, compound

HRID 2202787Notes

Reaction equation

HRID 2202787 reaction equation
C(OC([N:8]1[CH:13]2[CH2:14][CH2:15][CH:9]1[CH2:10][C:11]([OH:23])([C:16]1[C:21]([CH3:22])=[N:20][CH:19]=[CH:18][N:17]=1)[CH2:12]2)=O)(C)(C)C>Cl.O1CCOCC1>[CH3:22][C:21]1[C:16]([C:11]2([OH:23])[CH2:10][CH:9]3[NH:8][CH:13]([CH2:14][CH2:15]3)[CH2:12]2)=[N:17][CH:18]=[CH:19][N:20]=1

Participants

4

Reactant 1

HCID 67467267HCID 67467267, compound

Product 1

HCID 67462180HCID 67462180, compound

Reagents, catalysts & solvents 2

HCID 313Hydrochloric AcidSolventHCID 312751,4-DioxaneSolvent

Procedure

3-Hydroxy-3-(3-methyl-pyrazin-2-yl)-8-aza-bicyclo[3.2.1]octane-8-carboxylic acid tert-butyl ester (0.1 g, 0.41 mmol) was dissolved in a solution of hydrogen chloride in dioxane (4 N, 1.5 mL). The mixture was stirred for 1 hour and the solvent removed by evaporation under vacuum to afford the title compound. LCMS m/z 220.1 [M+H]+. R.T.=0.34 min (Analytical Method 3).

Workup

  1. customthe solvent removed by evaporation under vacuum

Sources & evidence

ORD record
ord-6078360ccf6f4f4eae613897172e8fb3
Source dataset
uspto-grants-2016_06
Patent number
US09365564B2

Reaction notes

Loading…