Hydrochloric Acid → HCID 86684822, compound

HRID 2202793Notes

Reaction equation

HRID 2202793 reaction equation
C(OC([N:8]1[CH:13]2[CH2:14][CH2:15][CH:9]1[CH2:10][C:11]([OH:21])([C:16]1[O:17][CH:18]=[CH:19][N:20]=1)[CH2:12]2)=O)(C)(C)C.[ClH:22]>O1CCOCC1>[ClH:22].[O:17]1[CH:18]=[CH:19][N:20]=[C:16]1[C:11]1([OH:21])[CH2:12][CH:13]2[NH:8][CH:9]([CH2:15][CH2:14]2)[CH2:10]1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 67462773HCID 67462773, compound

Product 1

HCID 86684822HCID 86684822, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

3-Hydroxy-3-oxazol-2-yl-8-aza-bicyclo[3.2.1]octane-8-carboxylic acid tert-butyl ester (0.3 g) was dissolved in a solution of hydrogen chloride in dioxane (4 N, 4 mL). The mixture was stirred for 1 hour and the solvent removed by evaporation under vacuum. The solid was triturated from ether to afford the title compound (0.28 g). LCMS m/z 195.2 [M+H]+. R.T.=0.35 min (Analytical Method 3).

Workup

  1. customthe solvent removed by evaporation under vacuum
  2. customThe solid was triturated from ether

Sources & evidence

ORD record
ord-c417f57ba26a4a5da5ae38abd8285db6
Source dataset
uspto-grants-2016_06
Patent number
US09365564B2

Reaction notes

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