Hydrochloric Acid → HCID 67462440, compound

HRID 2202795Notes

Reaction equation

HRID 2202795 reaction equation
C(OC([N:8]1[CH:13]2[CH2:14][CH2:15][CH:9]1[CH2:10][C:11]([OH:22])([C:16]1[N:17]=[N:18][CH:19]=[CH:20][CH:21]=1)[CH2:12]2)=O)(C)(C)C.[ClH:23]>O1CCOCC1>[ClH:23].[N:18]1[CH:19]=[CH:20][CH:21]=[C:16]([C:11]2([OH:22])[CH2:12][CH:13]3[NH:8][CH:9]([CH2:15][CH2:14]3)[CH2:10]2)[N:17]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 67466849HCID 67466849, compound

Product 1

HCID 67462440HCID 67462440, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

3-Hydroxy-3-pyridazin-3-yl-8-aza-bicyclo[3.2.1]octane-8-carboxylic acid tert-butyl ester (0.22 g) was dissolved in a solution of hydrogen chloride in dioxane (4 N, 2.5 mL). The mixture was stirred for 0.5 hours and the solvent removed by evaporation under vacuum. The solid was triturated from ether to afford the title compound (0.22 g). LCMS m/z 206.2 [M+H]+. R.T.=0.35 min. (Analytical Method 3).

Workup

  1. customthe solvent removed by evaporation under vacuum
  2. customThe solid was triturated from ether

Sources & evidence

ORD record
ord-ff869b9da1f14df493ef211cc2b7c095
Source dataset
uspto-grants-2016_06
Patent number
US09365564B2

Reaction notes

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