Hydrochloric Acid → HCID 67466201, compound

HRID 2202797Notes

Reaction equation

HRID 2202797 reaction equation
C(OC([N:8]1[CH:13]2[CH2:14][CH2:15][CH:9]1[CH2:10][C:11]([OH:21])([C:16]1[N:17]=[CH:18][S:19][CH:20]=1)[CH2:12]2)=O)(C)(C)C.[ClH:22]>O1CCOCC1>[ClH:22].[S:19]1[CH:20]=[C:16]([C:11]2([OH:21])[CH2:12][CH:13]3[NH:8][CH:9]([CH2:15][CH2:14]3)[CH2:10]2)[N:17]=[CH:18]1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 67463330HCID 67463330, compound

Product 1

HCID 67466201HCID 67466201, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Conditions

Temperature
45 °C

Procedure

3-Hydroxy-3-thiazol-4-yl-8-aza-bicyclo[3.2.1]octane-8-carboxylic acid tert-butyl ester (0.22 g) was dissolved in a solution of hydrogen chloride in dioxane (4 N, 2.5 mL). The mixture was stirred for 0.5 hours at 45° C. and the solvent removed by evaporation under vacuum. The solid was triturated from ether to afford the title compound (0.20 g). LCMS m/z 211.1 [M+H]+. R.T.=0.35 min. (Analytical Method 3).

Workup

  1. customthe solvent removed by evaporation under vacuum
  2. customThe solid was triturated from ether

Sources & evidence

ORD record
ord-ba89b94b5b9441ccbc48cd283513c708
Source dataset
uspto-grants-2016_06
Patent number
US09365564B2

Reaction notes

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