Dichloromethane → HCID 67468353, compound

HRID 2202801Notes

Reaction equation

HRID 2202801 reaction equation
C(OC([N:8]1[CH:13]2[CH2:14][CH2:15][CH:9]1[CH2:10][C:11]([OH:22])([C:16]1[CH:17]=[N:18][CH:19]=[N:20][CH:21]=1)[CH2:12]2)=O)(C)(C)C.C(Cl)[Cl:24]>Cl.O1CCOCC1>[ClH:24].[N:18]1[CH:17]=[C:16]([C:11]2([OH:22])[CH2:12][CH:13]3[NH:8][CH:9]([CH2:15][CH2:14]3)[CH2:10]2)[CH:21]=[N:20][CH:19]=1

Participants

5

Reactant 2

HCID 6344DichloromethaneHCID 67463235HCID 67463235, compound

Product 1

HCID 67468353HCID 67468353, compound

Reagents, catalysts & solvents 2

HCID 313Hydrochloric AcidSolventHCID 312751,4-DioxaneSolvent

Conditions

Temperature
45 °C

Procedure

3-Hydroxy-3-pyrimidin-5-yl-8-aza-bicyclo[3.2.1]octane-8-carboxylic acid tert-butyl ester (0.14 g, 0.46 mmol) was dissolved in a solution of hydrogen chloride in dioxane (4 N, 1.5 mL). The mixture was stirred for 1 hour at 45° C., DCM (3 mL) added and stirred for 5 minutes. The solvent was removed by evaporation under vacuum afford the title compound. LCMS m/z 206.3 [M+H]+. R.T.=2.90 min (Analytical Method 3).

Workup

  1. stirringstirred for 5 minutes
  2. customThe solvent was removed by evaporation under vacuum

Sources & evidence

ORD record
ord-0f732f6d3c0d4feabf179234286d3a80
Source dataset
uspto-grants-2016_06
Patent number
US09365564B2

Reaction notes

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