Dichloromethane → HCID 67462309, compound

HRID 2202805Notes

Reaction equation

HRID 2202805 reaction equation
C(OC([N:8]1[CH:13]2[CH2:14][CH2:15][CH:9]1[CH2:10][C:11]([O:23][CH3:24])([C:16]1[C:21]([CH3:22])=[CH:20][CH:19]=[CH:18][N:17]=1)[CH2:12]2)=O)(C)(C)C.C(Cl)[Cl:26]>Cl.O1CCOCC1>[ClH:26].[CH3:24][O:23][C:11]1([C:16]2[C:21]([CH3:22])=[CH:20][CH:19]=[CH:18][N:17]=2)[CH2:12][CH:13]2[NH:8][CH:9]([CH2:15][CH2:14]2)[CH2:10]1

Participants

5

Reactant 2

HCID 6344DichloromethaneHCID 67466946HCID 67466946, compound

Product 1

HCID 67462309HCID 67462309, compound

Reagents, catalysts & solvents 2

HCID 313Hydrochloric AcidSolventHCID 312751,4-DioxaneSolvent

Conditions

Temperature
50 °C

Procedure

3-Methoxy-3-(3-methyl-pyridin-2-yl)-8-aza-bicyclo[3.2.1]octane-8-carboxylic acid tert-butyl ester (0.09 g) was dissolved in a solution of hydrogen chloride in dioxane (4 N, 1.5 mL). The mixture was stirred for 1 hour at 50° C., DCM (3 mL) added and stirred for 5 minutes. The solvent was removed by evaporation under vacuum afford the title compound as a white solid. LCMS m/z 233.1 [M+H]+. R.T.=1.72 min (Analytical Method 3).

Workup

  1. stirringstirred for 5 minutes
  2. customThe solvent was removed by evaporation under vacuum

Sources & evidence

ORD record
ord-31ef896df0244e5cb281c605a2d78899
Source dataset
uspto-grants-2016_06
Patent number
US09365564B2

Reaction notes

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