HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2202807Generated: October 31, 2026
Hydrochloric Acid → 3-Thiazol-2-yl-8-aza-bicyclo[3.2.1]octane-3-carbonitrile hydrochloride
https://huagongshe.com/reaction/2202807
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | 3-Cyano-3-thiazol-2-yl-8-aza-bicyclo[3.2.1]octane-8-carboxylic acid tert-butyl ester | HCID 67464762 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | 3-Thiazol-2-yl-8-aza-bicyclo[3.2.1]octane-3-carbonitrile hydrochloride | HCID 67465255 | — |
Reaction Steps
3-Cyano-3-thiazol-2-yl-8-aza-bicyclo[3.2.1]octane-8-carboxylic acid tert-butyl ester (0.2 g) was dissolved in a solution of hydrogen chloride in dioxane (4 N, 3 mL). The mixture was stirred for 1 hour at 40° C. The solvent was removed by evaporation under vacuum afford the title compound as a white solid. LCMS m/z 220.1 [M+H]+. R.T.=0.58 min (Analytical Method 3).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US09365564B2 |
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| Source dataset | uspto-grants-2016_06 |
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| ORD ID | ord-21149732afa64d2e9074433ac635d3ec |
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| Source note | uspto-grants-2016_06 |
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