反应详情

温度

40 °C

3-Cyano-3-thiazol-2-yl-8-aza-bicyclo[3.2.1]octane-8-carboxylic acid tert-butyl ester (0.2 g) was dissolved in a solution of hydrogen chloride in dioxane (4 N, 3 mL). The mixture was stirred for 1 hour at 40° C. The solvent was removed by evaporation under vacuum afford the title compound as a white solid. LCMS m/z 220.1 [M+H]+. R.T.=0.58 min (Analytical Method 3).

1. customThe solvent was removed by evaporation under vacuum