Hydrochloric Acid → 3-Thiazol-2-yl-8-aza-bicyclo[3.2.1]octane-3-carbonitrile hydrochloride

HRID 2202807Notes

Reaction equation

C(OC([N:8]1[CH:13]2[CH2:14][CH2:15][CH:9]1[CH2:10][C:11]([C:21]#[N:22])([C:16]1[S:17][CH:18]=[CH:19][N:20]=1)[CH2:12]2)=O)(C)(C)C.[ClH:23]>O1CCOCC1>[ClH:23].[S:17]1[CH:18]=[CH:19][N:20]=[C:16]1[C:11]1([C:21]#[N:22])[CH2:12][CH:13]2[NH:8][CH:9]([CH2:15][CH2:14]2)[CH2:10]1

Participants

Conditions

Temperature: 40 °C

Procedure

3-Cyano-3-thiazol-2-yl-8-aza-bicyclo[3.2.1]octane-8-carboxylic acid tert-butyl ester (0.2 g) was dissolved in a solution of hydrogen chloride in dioxane (4 N, 3 mL). The mixture was stirred for 1 hour at 40° C. The solvent was removed by evaporation under vacuum afford the title compound as a white solid. LCMS m/z 220.1 [M+H]+. R.T.=0.58 min (Analytical Method 3).

Workup

customThe solvent was removed by evaporation under vacuum

Sources & evidence

ORD record: ord-21149732afa64d2e9074433ac635d3ec
Source dataset: uspto-grants-2016_06
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US09365564B2

Reaction notes

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