HCID 68209259, compound → HCID 89557215, compound

HRID 2202811Notes

Reaction equation

HRID 2202811 reaction equation
C(OC([N:8]1[CH2:13][CH2:12][C:11]([F:21])([C:14]2[C:19]([Cl:20])=[CH:18][CH:17]=[CH:16][N:15]=2)[CH2:10][CH2:9]1)=O)(C)(C)C>Cl.O1CCOCC1>[ClH:20].[Cl:20][C:19]1[C:14]([C:11]2([F:21])[CH2:10][CH2:9][NH:8][CH2:13][CH2:12]2)=[N:15][CH:16]=[CH:17][CH:18]=1

Participants

4

Reactant 1

HCID 68209259HCID 68209259, compound

Product 1

HCID 89557215HCID 89557215, compoundYield 194.2%

Reagents, catalysts & solvents 2

HCID 313Hydrochloric AcidSolventHCID 312751,4-DioxaneSolvent

Procedure

3-Chloro-4′-fluoro-3′,4′,5′,6′-tetrahydro-2′H-[2,4′]bipyridinyl-1′-carboxylic acid tert-butyl ester (0.13 g, 0.41 mmol) was dissolved in a solution of hydrogen chloride in dioxane (4 N, 2 mL). The mixture was stirred for 30 minutes and the solvent removed by evaporation under vacuum. The solid was triturated from ether to afford the title compound (0.10 g). LCMS m/z 215.28 [M+H]+. R.T.=1.87 min (Analytical Method 3).

Workup

  1. customthe solvent removed by evaporation under vacuum
  2. customThe solid was triturated from ether

Sources & evidence

ORD record
ord-7e9b8e9dc72641f5ae1fb54a5333e2a2
Source dataset
uspto-grants-2016_06
Patent number
US09365564B2

Reaction notes

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