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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2202830Generated: October 31, 2026

Trifluoroacetic acid → HCID 77231167, compound

https://huagongshe.com/reaction/2202830

Reaction equation

Participants

RoleNameHCIDCharge
ReactantTrifluoroacetic acidHCID 6422—
Reactanttert-Butyl 3-(5-methylpyridin-2-yl)azetidine-1-carboxylateHCID 71304644—
SolventDichloromethaneHCID 6344—
ProductHCID 77231167HCID 77231167—

Reaction Steps

To a solution of 126-2 (37 mg, 0.15 mmol) in DCM (4 mL) was added TFA (1 mL) and the reaction was stirred at room temperature for 2 h. The solvent was removed by rotary evaporation, followed by three cycles of dilution with DCM and evaporation to provide 126-3 that was used without further purification.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS09365562B2
Source datasetuspto-grants-2016_06
ORD IDord-86c2cbbb3c7c40b1971d866d61c7c384
Source noteuspto-grants-2016_06