Trifluoroacetic acid → HCID 77231167, compound

HRID 2202830Notes

Reaction equation

HRID 2202830 reaction equation
[CH3:1][C:2]1[CH:3]=[CH:4][C:5]([CH:8]2[CH2:11][N:10](C(OC(C)(C)C)=O)[CH2:9]2)=[N:6][CH:7]=1.C(O)(C(F)(F)F)=O>C(Cl)Cl>[NH:10]1[CH2:9][CH:8]([C:5]2[CH:4]=[CH:3][C:2]([CH3:1])=[CH:7][N:6]=2)[CH2:11]1

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 71304644tert-Butyl 3-(5-methylpyridin-2-yl)azetidine-1-carboxylate

Product 1

HCID 77231167HCID 77231167, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To a solution of 126-2 (37 mg, 0.15 mmol) in DCM (4 mL) was added TFA (1 mL) and the reaction was stirred at room temperature for 2 h. The solvent was removed by rotary evaporation, followed by three cycles of dilution with DCM and evaporation to provide 126-3 that was used without further purification.

Workup

  1. customThe solvent was removed by rotary evaporation
  2. customfollowed by three cycles of dilution with DCM and evaporation
  3. customto provide 126-3 that
  4. customwas used without further purification

Sources & evidence

ORD record
ord-86c2cbbb3c7c40b1971d866d61c7c384
Source dataset
uspto-grants-2016_06
Patent number
US09365562B2

Reaction notes

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