反应详情

To a stirred solution of pyrimidine-4,6-diol (2.5 g) in THF (25 ml) was added silver carbonate (15.3 g) at room temperature followed by dropwise addition of 4-chlorobenzyl bromide (4.58 g), and the resultant mixture was heated at reflux for 2 h. The reaction mixture was then cooled to room temperature, filtered through Celite, and the filtrate was concentrated in vacuo. The residue was purified by silica gel column chromatography (MeOH/DCM) to give the title compound (500 mg) as a white solid.

1. temperatureat reflux for 2 h
2. filtrationfiltered through Celite
3. concentrationthe filtrate was concentrated in vacuo
4. customThe residue was purified by silica gel column chromatography (MeOH/DCM)