HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-(Benzyloxy)-1-(2-ethyl-1-methyl-1H-benzimidazol-6-yl)pyridin-2(1H)-one → 1-(2-Ethyl-1-methyl-1H-benzimidazol-6-yl)-4-hydroxypyridin-2(1H)-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-(Benzyloxy)-1-(2-ethyl-1-methyl-1H-benzimidazol-6-yl)pyridin-2(1H)-one | HCID 89691078 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 1-(2-Ethyl-1-methyl-1H-benzimidazol-6-yl)-4-hydroxypyridin-2(1H)-one | HCID 89690998 | 61,012.898% |
Reaction Steps
A mixture of 4-(benzyloxy)-1-(2-ethyl-1-methyl-1H-benzimidazol-6-yl)pyridin-2(1H)-one (3.5 mg), Pd/C (10%, 700 mg) and MeOH (10 ml) was stirred under H2 atmosphere at room temperature for 2 h. The insoluble material was removed by filtration, and the filtrate was concentrated to give the title compound (1.6 g) as a white solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09365540B2 |
| Source dataset | uspto-grants-2016_06 |
| ORD ID | ord-422084a30eb448718fa93ccdf139e4e7 |
| Source note | uspto-grants-2016_06 |