HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2202908Generated: October 31, 2026
Anisole → 1-(2-cyclopropyl-1-methyl-1H-benzimidazol-6-yl)-4-hydroxypyridin-2(1H)-one
https://huagongshe.com/reaction/2202908
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Anisole | HCID 7519 | — |
| Reactant | 1-(2-Cyclopropyl-1-methyl-1H-benzimidazol-6-yl)-4-(phenylmethoxy)-2(1H)-pyridinone | HCID 89691032 | — |
| Solvent | Trifluoroacetic acid | HCID 6422 | — |
| Product | 1-(2-cyclopropyl-1-methyl-1H-benzimidazol-6-yl)-4-hydroxypyridin-2(1H)-one | HCID 89691084 | 122.3% |
Reaction Steps
To a stirred solution of 4-(benzyloxy)-1-(2-cyclopropyl-1-methyl-1H-benzimidazol-6-yl)pyridin-2(1H)-one (840 mg) in TFA (21 ml) was added anisole (7 ml), and the reaction mixture was heated at 130° C. for 4 h. The mixture was cooled and concentrated in vacuo. The residue was triturated with Et2O to give the title compound (778 mg) as a white solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US09365540B2 |
|---|
| Source dataset | uspto-grants-2016_06 |
|---|
| ORD ID | ord-e4beb310f545499faa289caf49b7fe4a |
|---|
| Source note | uspto-grants-2016_06 |
|---|
