Formaldehyde → Imidazo[1,2-a]pyridine-3-methanol, 2-cyclopropyl-6-iodo-

HRID 2202943Notes

Reaction equation

HRID 2202943 reaction equation
[CH:1]1([C:4]2[N:5]=[C:6]3[CH:11]=[CH:10][C:9]([I:12])=[CH:8][N:7]3[CH:13]=2)[CH2:3][CH2:2]1.[C:14]([O-])(=[O:16])C.[Na+].C=O>CC(O)=O>[CH:1]1([C:4]2[N:5]=[C:6]3[CH:11]=[CH:10][C:9]([I:12])=[CH:8][N:7]3[C:13]=2[CH2:14][OH:16])[CH2:3][CH2:2]1

Participants

5

Reactant 3

HCID 712FormaldehydeHCID 517045Sodium AcetateHCID 86811355HCID 86811355, compound

Product 1

HCID 89690296Imidazo[1,2-a]pyridine-3-methanol, 2-cyclopropyl-6-iodo-

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Conditions

Temperature
50 °C

Procedure

To a solution of 2-cyclopropyl-6-iodoimidazo[1,2-a]pyridine (1.5 g) in AcOH (20 ml) were added sodium acetate (2.39 g) and 40% aqueous formaldehyde solution (4 ml), and the mixture was heated at 50° C. for 6 h. The reaction mixture was then cooled to room temperature, and concentrated in vacuo.

Workup

  1. temperatureThe reaction mixture was then cooled to room temperature
  2. concentrationconcentrated in vacuo

Sources & evidence

ORD record
ord-3f29151d617f4a469f8051ccd2f66b5e
Source dataset
uspto-grants-2016_06
Patent number
US09365540B2

Reaction notes

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