Hydrazine hydrate (1:1) → HCID 89690276, compound

HRID 2202949Notes

Reaction equation

HRID 2202949 reaction equation
[I:1][C:2]1[CH:3]=[CH:4][C:5]2[N:6]([C:8]([CH3:16])=[C:9]([C:11](OCC)=[O:12])[N:10]=2)[CH:7]=1.O.[NH2:18][NH2:19]>CCO>[I:1][C:2]1[CH:3]=[CH:4][C:5]2[N:6]([C:8]([CH3:16])=[C:9]([C:11]([NH:18][NH2:19])=[O:12])[N:10]=2)[CH:7]=1

Participants

4

Reactant 2

HCID 24654Hydrazine hydrate (1:1)HCID 121386250HCID 121386250, compound

Product 1

HCID 89690276HCID 89690276, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Conditions

Temperature
80 °C

Procedure

To a stirred solution of ethyl 6-iodo-3-methylimidazo[1,2-a]pyridine-2-carboxylate (250 mg) in EtOH (5 ml) was added hydrazine hydrate (0.14 ml) at room temperature. The reaction vessel was sealed and heated at 80° C. for 16 h. The mixture was then cooled to room temperature, and the reaction mixture was concentrated in vacuo. The residue was washed with EtOAc to give the title compound (200 mg) as a light yellow solid.

Workup

  1. customThe reaction vessel was sealed
  2. temperatureThe mixture was then cooled to room temperature
  3. concentrationthe reaction mixture was concentrated in vacuo
  4. washThe residue was washed with EtOAc

Sources & evidence

ORD record
ord-d7b917dcb47a4774bc9a80ce5172510b
Source dataset
uspto-grants-2016_06
Patent number
US09365540B2

Reaction notes

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