HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2202982Generated: November 1, 2026
Anisole → 1-(2,3-Dimethylimidazo[1,2-a]pyridin-6-yl)-4-hydroxy-2(1h)-pyridinone
https://huagongshe.com/reaction/2202982
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Anisole | HCID 7519 | — |
| Reactant | 4-(benzyloxy)-1-(2,3-dimethylimidazo[1,2-a]pyridin-6-yl)pyridin-2(1H)-one | HCID 89690600 | — |
| Solvent | Trifluoroacetic acid | HCID 6422 | — |
| Product | 1-(2,3-Dimethylimidazo[1,2-a]pyridin-6-yl)-4-hydroxy-2(1h)-pyridinone | HCID 89690568 | 83.9% |
Reaction Steps
To a stirred solution of 4-(benzyloxy)-1-(2,3-dimethylimidazo[1,2-a]pyridin-6-yl)pyridin-2(1H)-one (500 mg) in TFA (21 ml) was added anisole (7 ml), and the reaction mixture was heated at 130° C. for 4 h. The mixture was concentrated in vacuo to afford the title compound (310 mg) as a white solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US09365540B2 |
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| Source dataset | uspto-grants-2016_06 |
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| ORD ID | ord-726eb8123bb64aacb13c6ae5117e92be |
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| Source note | uspto-grants-2016_06 |
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