Methanol → 5-(Trifluoromethyl)-3-thiophenemethanol

Temperature

60 °C

To a solution of methyl 5-(trifluoromethyl)thiophene-3-carboxylate (523 mg) in THF (1 ml)-MeOH (1 ml) was added NaBH4 (2.2 g) at room temperature, and the reaction mixture was stirred at 60° C. for 3 h. The reaction mixture was quenched with water, and extracted with EtOAc. The extract was washed with brine, dried over MgSO4, concentrated and purified by silica gel column chromatography (hexane/EtOAc) to give the title compound (449 mg) as a pale yellow oil.

1. customThe reaction mixture was quenched with water
2. extractionextracted with EtOAc
3. washThe extract was washed with brine
4. dry with materialdried over MgSO4
5. concentrationconcentrated
6. custompurified by silica gel column chromatography (hexane/EtOAc)

ORD record

ord-1e2c80422bdb4179887d3c9cdb8d9899

Source dataset

uspto-grants-2016_06

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US09365540B2