Methanol → 3-Thiophenemethanol, 5-(difluoromethyl)-

Temperature

60 °C

To a solution of methyl 5-(difluoromethyl)thiophene-3-carboxylate (267 mg) in THF (5 ml)-MeOH (1 ml) was added NaBH4 (263 mg) at room temperature, and the reaction mixture was stirred at 60° C. for 1 h. The reaction mixture was quenched with water, and extracted with EtOAc. The extract was washed with brine, dried over MgSO4, concentrated and purified by silica gel column chromatography (hexane/EtOAc) to give the title compound (192 mg) as a colorless oil.

1. customThe reaction mixture was quenched with water
2. extractionextracted with EtOAc
3. washThe extract was washed with brine
4. dry with materialdried over MgSO4
5. concentrationconcentrated
6. custompurified by silica gel column chromatography (hexane/EtOAc)

ORD record

ord-d6fdcb311adf40d7ab109ce7274a82da

Source dataset

uspto-grants-2016_06

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US09365540B2