Hydroxyamine hydrochloride → HCID 89691114, compound

HRID 2203047Notes

Reaction equation

HRID 2203047 reaction equation
[Br:1][C:2]1[CH:3]=[CH:4][C:5]2[N:9]=[C:8]([CH:10]3[CH2:13][CH:12]([CH:14]=O)[CH2:11]3)[N:7]([CH3:16])[C:6]=2[CH:17]=1.Cl.[NH2:19][OH:20]>CCO>[Br:1][C:2]1[CH:3]=[CH:4][C:5]2[N:9]=[C:8]([CH:10]3[CH2:13][CH:12]([CH:14]=[N:19][OH:20])[CH2:11]3)[N:7]([CH3:16])[C:6]=2[CH:17]=1

Participants

4

Reactant 2

HCID 443297Hydroxyamine hydrochlorideHCID 89691132HCID 89691132, compound

Product 1

HCID 89691114HCID 89691114, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

To a stirred solution of 3-(6-bromo-1-methyl-1H-benzimidazol-2-yl)cyclobutanecarbaldehyde (less polar isomer, 200 mg) in EtOH (10 ml) was added hydroxylamine hydrochloride (50 mg), and the resulting mixture was heated under reflux for 2 h. The reaction mixture was concentrated in vacuo to afford the title compound (200 mg) as an off-white solid.

Workup

  1. temperaturethe resulting mixture was heated
  2. temperatureunder reflux for 2 h
  3. concentrationThe reaction mixture was concentrated in vacuo

Sources & evidence

ORD record
ord-5ec8024fed5c4231b54b47faa6811c53
Source dataset
uspto-grants-2016_06
Patent number
US09365540B2

Reaction notes

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