Cyclopropanecarbonyl chloride → HCID 91065228, compound

HRID 220306Notes

Reaction equation

[Cl:1][C:2]1[C:32]([Cl:33])=[CH:31][C:5]2[NH:6][C:7]([CH2:9][CH2:10][CH2:11][N:12]([CH3:30])[CH2:13][CH2:14][C:15]3([OH:29])[CH2:20][CH:19]4[CH2:21][CH2:22][CH:16]3[CH:17]=[C:18]4[C:23]3[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=3)=[N:8][C:4]=2[CH:3]=1.[CH:34]1([C:37](Cl)=[O:38])[CH2:36][CH2:35]1>>[Cl:33][C:32]1[C:2]([Cl:1])=[CH:3][C:4]2[NH:8][C:7]([CH2:9][CH2:10][CH2:11][N:12]([CH3:30])[CH2:13][CH2:14][C@:15]3([O:29][C:37]([CH:34]4[CH2:36][CH2:35]4)=[O:38])[CH2:20][C@H:19]4[CH2:21][CH2:22][C@@H:16]3[CH:17]=[C:18]4[C:23]3[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=3)=[N:6][C:5]=2[CH:31]=1

Participants

Reactant 2

HCID 77637Cyclopropanecarbonyl chloride

HCID 68415577HCID 68415577, compound

Product 1

HCID 91065228HCID 91065228, compound

Procedure

Prepared according to procedure P1.4 in Example 1A using rac-(1R*,2R*,4R*)-2-(2-{[3-(5,6-dichloro-1H-benzoimidazol-2-yl)-propyl]-methyl-amino}-ethyl)-5-phenyl-bicyclo[2.2.2]oct-5-en-2-ol and cyclopropancarbonyl chloride.

Workup

customPrepared

Sources & evidence

ORD record: ord-626f3bebecca45f19cbcd93b9ab73360
Source dataset: uspto-grants-2012_06
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08202885B2

Reaction notes

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