HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-(benzyloxy)-1-(1,2-dimethyl-1H-benzimidazol-6-yl)pyridin-2(1H)-one → 1-(1,2-Dimethyl-1H-benzimidazol-6-yl)-4-hydroxypyridin-2(1H)-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-(benzyloxy)-1-(1,2-dimethyl-1H-benzimidazol-6-yl)pyridin-2(1H)-one | HCID 89691195 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 1-(1,2-Dimethyl-1H-benzimidazol-6-yl)-4-hydroxypyridin-2(1H)-one | HCID 89690967 | 90.9% |
Reaction Steps
A mixture of 4-(benzyloxy)-1-(1,2-dimethyl-1H-benzimidazol-6-yl)pyridin-2(1H)-one (627 mg), 10% Pd/C (193 mg) and MeOH (10 ml) was stirred under H2 atmosphere at room temperature for 1 h. The catalyst was removed by filtration, and the filtrate was concentrated in vacuo to give the title compound (421 mg) as white crystals.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09365540B2 |
| Source dataset | uspto-grants-2016_06 |
| ORD ID | ord-181c4a7519de4a6d814132b0da56589f |
| Source note | uspto-grants-2016_06 |