反应详情

To a solution of compound 3, at 0° C. and under nitrogen atmosphere, in chloroform (0.3M) was added acetic anhydride (2.3 equiv.) drop wise and the resulting mixture was stirred for 1 h at r.t. Then potassium acetate (0.2 equiv.) was added followed by addition of isoamyl nitrite (2.2 equiv.) and the resulting mixture was heated at reflux for 16 h. After, the reaction was cooled down to r.t. While cooling, a solid precipitation was observed. The solid was filtrated and dried under vacuum to give the title compound 4. (0.324 g, 75%).

1. temperaturethe resulting mixture was heated
2. temperatureat reflux for 16 h
3. temperatureAfter, the reaction was cooled down to r.t
4. temperatureWhile cooling
5. customa solid precipitation
6. filtrationThe solid was filtrated
7. customdried under vacuum