Isobutyl iodide → 5-Fluoro-1-isobutyl-1H-indazole-7-carboxylic acid methyl ester
Reaction equation
[CH3:1][O:2][C:3]([C:5]1[CH:6]=[C:7]([F:14])[CH:8]=[C:9]2[C:13]=1[NH:12][N:11]=[CH:10]2)=[O:4].I[CH2:16][CH:17]([CH3:19])[CH3:18]>>[CH3:1][O:2][C:3]([C:5]1[CH:6]=[C:7]([F:14])[CH:8]=[C:9]2[C:13]=1[N:12]([CH2:16][CH:17]([CH3:19])[CH3:18])[N:11]=[CH:10]2)=[O:4]Participants
3
Procedure
Compound 11 was prepared following general method 1, using 5-fluoro-1H-indazole-7-carboxylic acid methyl ester (see WO2011008572, incorporated by reference in its entirety) as starting material and 1-iodo-2-methylpropane as alkylating agent. Yield: 41%.
Sources & evidence
- ORD record
- ord-eafa903817f4472eaba8444abc744e49
- Source dataset
- uspto-grants-2016_06
- Patent number
- US09365569B2
Reaction notes
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