Isobutyl iodide → 1-Isobutyl-5-trifluoromethyl-1H-indazole-7-carboxylic acid methyl ester

HRID 2203160Notes

Reaction equation

HRID 2203160 reaction equation
[F:1][C:2]([F:17])([F:16])[C:3]1[CH:4]=[C:5]2[C:9](=[C:10]([C:12]([O:14][CH3:15])=[O:13])[CH:11]=1)[NH:8][N:7]=[CH:6]2.I[CH2:19][CH:20]([CH3:22])[CH3:21]>>[CH3:15][O:14][C:12]([C:10]1[CH:11]=[C:3]([C:2]([F:1])([F:16])[F:17])[CH:4]=[C:5]2[C:9]=1[N:8]([CH2:19][CH:20]([CH3:22])[CH3:21])[N:7]=[CH:6]2)=[O:13]

Participants

3

Reactant 2

HCID 10556Isobutyl iodideHCID 118251578Methyl 5-(trifluoromethyl)-1H-indazole-7-carboxylate

Product 1

HCID 1182515991-Isobutyl-5-trifluoromethyl-1H-indazole-7-carboxylic acid methyl esterYield 39%

Procedure

Compound 12 was prepared following general method 1, using compound 4 as starting material and 1-iodo-2-methylpropane as alkylating agent. Yield: 39%.

Sources & evidence

ORD record
ord-12de4b2f41bc469b939ca02c6ea13615
Source dataset
uspto-grants-2016_06
Patent number
US09365569B2

Reaction notes

Loading…