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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2203160Generated: November 1, 2026

Isobutyl iodide → 1-Isobutyl-5-trifluoromethyl-1H-indazole-7-carboxylic acid methyl ester

https://huagongshe.com/reaction/2203160

Reaction equation

Participants

RoleNameHCIDCharge
ReactantIsobutyl iodideHCID 10556—
ReactantMethyl 5-(trifluoromethyl)-1H-indazole-7-carboxylateHCID 118251578—
Product1-Isobutyl-5-trifluoromethyl-1H-indazole-7-carboxylic acid methyl esterHCID 11825159939%

Reaction Steps

Compound 12 was prepared following general method 1, using compound 4 as starting material and 1-iodo-2-methylpropane as alkylating agent. Yield: 39%.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS09365569B2
Source datasetuspto-grants-2016_06
ORD IDord-12de4b2f41bc469b939ca02c6ea13615
Source noteuspto-grants-2016_06