1-Iodopropane → HCID 118251623, compound

HRID 2203164Notes

Reaction equation

[CH3:1][O:2][C:3]([C:5]1[CH:6]=[C:7]([Cl:14])[CH:8]=[C:9]2[C:13]=1[NH:12][N:11]=[CH:10]2)=[O:4].I[CH2:16][CH2:17][CH3:18]>>[CH3:1][O:2][C:3]([C:5]1[CH:6]=[C:7]([Cl:14])[CH:8]=[C:9]2[C:13]=1[N:12]([CH2:16][CH2:17][CH3:18])[N:11]=[CH:10]2)=[O:4]

Participants

Reactant 2

HCID 336431-Iodopropane

HCID 53419723HCID 53419723, compound

Product 1

HCID 118251623HCID 118251623, compoundYield 39%

Procedure

Compound 16 was prepared following general method 1, using 5-chloro-1H-indazole-7-carboxylic acid methyl ester (WO2011008572) as a starting material and 1-iodopropane as alkylating agent. Yield: 39%.

Sources & evidence

ORD record: ord-34e8273ba63b4c6b9a44446eb90fef97
Source dataset: uspto-grants-2016_06
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US09365569B2

Reaction notes

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