Methyl 1H-indazole-5-carboxylate → 1-(1-Isobutyl-5-trifluoromethoxy-1H-indazol-7-ylmethyl)-1H-indazole-5-carboxylic acid methyl ester

HRID 2203168Notes

Reaction equation

HRID 2203168 reaction equation
[CH2:1]([N:5]1[C:13]2[C:8](=[CH:9][C:10]([O:16][C:17]([F:20])([F:19])[F:18])=[CH:11][C:12]=2[CH2:14]O)[CH:7]=[N:6]1)[CH:2]([CH3:4])[CH3:3].[CH3:21][O:22][C:23]([C:25]1[CH:26]=[C:27]2[C:31](=[CH:32][CH:33]=1)[NH:30][N:29]=[CH:28]2)=[O:24]>>[CH3:21][O:22][C:23]([C:25]1[CH:26]=[C:27]2[C:31](=[CH:32][CH:33]=1)[N:30]([CH2:7][C:8]1[CH:9]=[C:10]([O:16][C:17]([F:18])([F:20])[F:19])[CH:11]=[C:12]3[C:13]=1[N:5]([CH2:1][CH:2]([CH3:4])[CH3:3])[N:6]=[CH:14]3)[N:29]=[CH:28]2)=[O:24]

Participants

3

Reactant 2

HCID 22260640Methyl 1H-indazole-5-carboxylateHCID 118251620(1-Isobutyl-5-trifluoromethoxy-1H-indazole-7-yl)-methanol

Product 1

HCID 1182516291-(1-Isobutyl-5-trifluoromethoxy-1H-indazol-7-ylmethyl)-1H-indazole-5-carboxylic acid methyl esterYield 46%

Procedure

Compound 29 was prepared following general method 3A, using compound 21 as a starting material and 1H-indazole-5-carboxylic acid methyl ester as the heterocycle. Yield: 46%.

Sources & evidence

ORD record
ord-420e52b726c8470c8b7d9f0d1747dc8a
Source dataset
uspto-grants-2016_06
Patent number
US09365569B2

Reaction notes

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