(1-Isobutyl-5-trifluoromethoxy-1H-indazole-7-yl)-methanol → 1-(1-Isobutyl-5-trifluoromethoxy-1H-indazol-7-ylmethyl)-1H-benzoimidazole-5-carboxylic acid methyl ester

HRID 2203177Notes

Reaction equation

HRID 2203177 reaction equation
[CH2:1]([N:5]1[C:13]2[C:8](=[CH:9][C:10]([O:16][C:17]([F:20])([F:19])[F:18])=[CH:11][C:12]=2[CH2:14]O)[CH:7]=[N:6]1)[CH:2]([CH3:4])[CH3:3].[CH3:21][O:22][C:23]([C:25]1[CH:33]=[CH:32][C:28]2[NH:29][CH:30]=[N:31][C:27]=2[CH:26]=1)=[O:24]>>[CH3:21][O:22][C:23]([C:25]1[CH:33]=[CH:32][C:28]2[N:29]([CH2:14][C:12]3[CH:11]=[C:10]([O:16][C:17]([F:20])([F:19])[F:18])[CH:9]=[C:8]4[C:13]=3[N:5]([CH2:1][CH:2]([CH3:4])[CH3:3])[N:6]=[CH:7]4)[CH:30]=[N:31][C:27]=2[CH:26]=1)=[O:24]

Participants

3

Reactant 2

HCID 118251620(1-Isobutyl-5-trifluoromethoxy-1H-indazole-7-yl)-methanolHCID 178497374HCID 178497374, compound

Product 1

HCID 1182515771-(1-Isobutyl-5-trifluoromethoxy-1H-indazol-7-ylmethyl)-1H-benzoimidazole-5-carboxylic acid methyl esterYield 65%

Procedure

Compound 40 was prepared following general method 3A, using compound 21 as a starting material and 1H-benzoimidazole-5-carboxylic acid methyl ester as the heterocycle. Yield: 65%.

Sources & evidence

ORD record
ord-1ad57aec509143299ffc91eca168c21f
Source dataset
uspto-grants-2016_06
Patent number
US09365569B2

Reaction notes

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