反应详情

温度

60 °C

A mixture of compound 67 (0.054 g, 0.13 mmol), p-toluenesulphonic acid (0.003 g, 0.013 mmol), in trimethylorthoformate (3 mL) was heated at 100° C. in a closed vessel for 16 h. Then, the reaction was concentrated to dryness under vaccum. The residue was dissolved in tetrahydrofuran (4 mL), sodium borohydride was added (0.015 g, 0.395 mmol) and the resulting mixture was heated at 60° C. for 5 h.

1. concentrationThen, the reaction was concentrated to dryness under vaccum
2. dissolutionThe residue was dissolved in tetrahydrofuran (4 mL)
3. additionsodium borohydride was added (0.015 g, 0.395 mmol)