Triethylamine → HCID 23158329, compound

HRID 2203218Notes

Reaction equation

HRID 2203218 reaction equation
[Br:1][C:2]1[CH:11]=[CH:10][C:5]([C:6]([O:8]C)=O)=[C:4]([CH2:12]Br)[CH:3]=1.[NH2:14][CH2:15][CH2:16][C:17]([CH3:20])([OH:19])[CH3:18].CCN(CC)CC>CO>[Br:1][C:2]1[CH:3]=[C:4]2[C:5](=[CH:10][CH:11]=1)[C:6](=[O:8])[N:14]([CH2:15][CH2:16][C:17]([OH:19])([CH3:20])[CH3:18])[CH2:12]2

Participants

5

Reactant 3

HCID 8471TriethylamineHCID 156491734-Amino-2-methylbutan-2-olHCID 22031079Methyl 4-bromo-2-(bromomethyl)benzoate

Product 1

HCID 23158329HCID 23158329, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Conditions

Temperature
85 °C

Procedure

To methyl 4-bromo-2-(bromomethyl)benzoate (0.220 g, 0.714 mmol) suspended in MeOH (6.0 mL) were added 4-amino-2-methylbutan-2-ol (0.077 g, 0.750 mmol) and Et3N (0.156 mL, 1.107 mmol). The mixture was heated to reflux (85° C.) for 24 hours, then cooled to RT, and concentrated in vacuo to give the title compound, which was used without further purification.

Workup

  1. temperatureThe mixture was heated
  2. temperaturecooled to RT
  3. concentrationconcentrated in vacuo

Sources & evidence

ORD record
ord-b4703082cc7f4b1f9aa93a2627270c78
Source dataset
uspto-grants-2016_06
Patent number
US09365566B2

Reaction notes

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