反应详情

To a solution of the intermediate from Step B (5.96 g, 56.7 mmol) in MeOH (35 mL) was added 6N HCl (20.89 mL, 125 mmol) followed by Pd/C (0.905 g, 8.51 mmol). The reaction mixture was kept on Parr shaker for 2 hours at 40 psig hydrogen. The reaction mixture was filtered through Celite™ (diatomaceous earth) and washed with 600 mL of MeOH and the filtrate concentrated. The residue was azeotroped several times with toluene. A dark brown solid was obtained. m/z=110 (M+H).

1. filtrationThe reaction mixture was filtered through Celite™ (diatomaceous earth)
2. washwashed with 600 mL of MeOH
3. concentrationthe filtrate concentrated
4. customThe residue was azeotroped several times with toluene
5. customA dark brown solid was obtained