Dimethylamine → HCID 58118759, compound

HRID 2203396Notes

Reaction equation

HRID 2203396 reaction equation
Br[CH2:2][CH:3]1[CH2:8][CH2:7][O:6][CH2:5][CH2:4]1.[Na+].[Cl-].[CH3:11][NH:12][CH3:13]>>[CH3:11][N:12]([CH3:13])[CH2:2][CH:3]1[CH2:8][CH2:7][O:6][CH2:5][CH2:4]1

Participants

4

Reactant 3

HCID 674DimethylamineHCID 5234Sodium ChlorideHCID 27732864-(Bromomethyl)oxane

Product 1

HCID 58118759HCID 58118759, compound

Procedure

4-(Bromomethyl)tetrahydro-2H-pyran (0.50 g, 2.8 mmol) was dissolved in dimethylamine (40% in water, 5 mL) and the reaction mixture was stirred at RT for 18 hours. The mixture was saturated with NaCl and extracted into Et2O (2×). The combined organic extract was dried (K2CO3), filtered and concentrated in vacuo to give the title compound as a colourless oil (0.40 g).

Workup

  1. extractionextracted into Et2O (2×)
  2. extractionThe combined organic extract
  3. dry with materialwas dried (K2CO3)
  4. filtrationfiltered
  5. concentrationconcentrated in vacuo

Sources & evidence

ORD record
ord-31a203dfaad54712b97ad6c3733e9c4a
Source dataset
uspto-grants-2016_06
Patent number
US09365577B2

Reaction notes

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