反应详情

温度

65 °C

A solution of 3-chloro-propane-1-sulfonic acid dimethylamide (0.55 g, 3.00 mmol) in MeCN (5 mL) was treated with dimethylamine (2 M in THF; 10 mL, 20 mmol), potassium carbonate (455 mg, 3.30 mmol) and a catalytic amount of potassium iodide (50 mg, 0.03 mmol). This mixture was heated in a sealed tube at 65° C. for 18 hours, then cooled and diluted with water and extracted into EtOAc. The organic extract was washed with brine then dried (Na2SO4), filtered and concentrated in vacuo to afford the title compound as a pale brown oil (0.40 g).

1. temperaturecooled
2. extractionextracted into EtOAc
3. extractionThe organic extract
4. washwas washed with brine
5. dry with materialthen dried (Na2SO4)
6. filtrationfiltered
7. concentrationconcentrated in vacuo