Hydrochloric Acid → N-(4-aminobutyl)methanesulfonamide hydrochloride
Reaction equation
[ClH:1].C(OC(=O)[NH:8][CH2:9][CH2:10][CH2:11][CH2:12][NH:13][S:14]([CH3:17])(=[O:16])=[O:15])(C)(C)C>C(O)C>[ClH:1].[NH2:8][CH2:9][CH2:10][CH2:11][CH2:12][NH:13][S:14]([CH3:17])(=[O:16])=[O:15]Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Conditions
- Temperature
- 100 °C
Procedure
A solution of hydrochloric acid in ethanol was added to a solution of tert-butyl[4-(methanesulfonylamino)butyl]carbamate (18.9 g, 71.1 mmol) in ethanol (100 mL), and the reaction was heated at 100° C. for two hours. The solvent was removed under reduced pressure. A mixture of dichloromethane:hexanes was added to the resulting oil and removed under reduced pressure; this process was repeated several times. The residue was dried for three days under vacuum to provide 14.3 g of N-(4-aminobutyl)methanesulfonamide hydrochloride as a tan solid.
Workup
- customThe solvent was removed under reduced pressure
- additionA mixture of dichloromethane
- additionhexanes was added to the resulting oil
- customremoved under reduced pressure
- customThe residue was dried for three days under vacuum
Sources & evidence
- ORD record
- ord-5df97d12b5114fe798b2b7ca06958c0b
- Source dataset
- uspto-grants-2016_06
- Patent number
- US09365567B2
Reaction notes
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