Pyrrolidine → HCID 58180504, compound

HRID 220367Notes

Reaction equation

[NH:1]1[CH2:5][CH2:4][CH2:3][CH2:2]1.[CH:6]1([N:9]([CH:36]2[CH2:38][CH2:37]2)[C:10]([C:12]2[N:33]([CH2:34][CH3:35])[C:15]3=[N:16][C:17]([NH:24][C:25]4[S:26][C:27]([C:30](O)=[O:31])=[CH:28][N:29]=4)=[C:18]4[N:22]=[CH:21][N:20]([CH3:23])[C:19]4=[C:14]3[CH:13]=2)=[O:11])[CH2:8][CH2:7]1>>[CH:36]1([N:9]([CH:6]2[CH2:7][CH2:8]2)[C:10]([C:12]2[N:33]([CH2:34][CH3:35])[C:15]3=[N:16][C:17]([NH:24][C:25]4[S:26][C:27]([C:30]([N:1]5[CH2:5][CH2:4][CH2:3][CH2:2]5)=[O:31])=[CH:28][N:29]=4)=[C:18]4[N:22]=[CH:21][N:20]([CH3:23])[C:19]4=[C:14]3[CH:13]=2)=[O:11])[CH2:37][CH2:38]1

Participants

Reactant 2

HCID 31268Pyrrolidine

HCID 58180599HCID 58180599, compound

Product 1

HCID 58180504HCID 58180504, compound

Procedure

This compound was prepared according to Example 20 using pyrrolidine and 2-(7-(dicyclopropylcarbamoyl)-6-ethyl-1-methyl-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridin-4-ylamino)thiazole-5-carboxylic acid (example 20A) to provide N,N-dicyclopropyl-6-ethyl-1-methyl-4-(5-(pyrrolidine-1-carbonyl)thiazol-2-ylamino)-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridine-7-carboxamide

Workup

customThis compound was prepared

Sources & evidence

ORD record: ord-8558c536ee2c421a9c580f7dbb129e30
Source dataset: uspto-grants-2012_06
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08202881B2

Reaction notes

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