Nitric Acid → HCID 60205312, compound

HRID 2203750Notes

Reaction equation

HRID 2203750 reaction equation
[F:1][C:2]1[C:7]([F:8])=[CH:6][N:5]=[C:4]2[NH:9][CH:10]=[CH:11][C:3]=12.[N+:12]([O-])([OH:14])=[O:13]>O>[F:1][C:2]1[C:7]([F:8])=[CH:6][N:5]=[C:4]2[NH:9][CH:10]=[C:11]([N+:12]([O-:14])=[O:13])[C:3]=12

Participants

4

Reactant 2

HCID 944Nitric AcidHCID 534382594,5-Difluoro-1H-pyrrolo[2,3-b]pyridine

Product 1

HCID 60205312HCID 60205312, compoundYield 80%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

4,5-Difluoro-1H-pyrrolo[2,3-b]pyridine (0.63 g, 4.09 mmol) was added slowly to fuming nitric acid (8.18 mL, 164 mmol) at 0° C. and stirred slowly for 5 minutes. Ice (20 g) was added followed by water (40 mL). The solid formed was collected by filtration to give 4,5-difluoro-3-nitro-1H-pyrrolo[2,3-b]pyridine (0.65 g, 80% yield) as a solid.

Workup

  1. customThe solid formed
  2. filtrationwas collected by filtration

Sources & evidence

ORD record
ord-f62cfd6b0d6f45eea90c31957692fce7
Source dataset
uspto-grants-2016_06
Patent number
US09365568B2

Reaction notes

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