HuagongsheHuagongshe Chemistry Print Report · For research reference only
Nitric Acid → HCID 60205312, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Nitric Acid | HCID 944 | — |
| Reactant | 4,5-Difluoro-1H-pyrrolo[2,3-b]pyridine | HCID 53438259 | — |
| Solvent | Water | HCID 962 | — |
| Product | HCID 60205312 | HCID 60205312 | 80% |
Reaction Steps
4,5-Difluoro-1H-pyrrolo[2,3-b]pyridine (0.63 g, 4.09 mmol) was added slowly to fuming nitric acid (8.18 mL, 164 mmol) at 0° C. and stirred slowly for 5 minutes. Ice (20 g) was added followed by water (40 mL). The solid formed was collected by filtration to give 4,5-difluoro-3-nitro-1H-pyrrolo[2,3-b]pyridine (0.65 g, 80% yield) as a solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09365568B2 |
| Source dataset | uspto-grants-2016_06 |
| ORD ID | ord-f62cfd6b0d6f45eea90c31957692fce7 |
| Source note | uspto-grants-2016_06 |