反应详情

To a stirred suspension of decane-1,10-diol (3 g, 17.21 mmol), benzyl bromide (2.25 ml, 18.94 mmol) and Ag2O (5.98 g, 25.82 mmol) in dry DCM (50 ml) were added, the reaction mixture was refluxed overnight, then the Ag2O was filtered off. The crude product was purified by silica gel column (10% EtOAc in Hexane) to afford 10-(benzyloxy)decan-1-ol as a gummy colorless liquid (2.96 g, 65%).

1. additionwere added
2. temperaturethe reaction mixture was refluxed overnight
3. filtrationthe Ag2O was filtered off
4. customThe crude product was purified by silica gel column (10% EtOAc in Hexane)