Methanol → Methyl 8-bromooctanoate

HRID 2204059Notes

Reaction equation

[Br:1][CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][C:9]([OH:11])=[O:10].OS(O)(=O)=O.[CH3:17]O>>[Br:1][CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][C:9]([O:11][CH3:17])=[O:10]

Participants

Reactant 3

HCID 887Methanol

HCID 1118Sulfuric Acid

HCID 5482758-Bromooctanoic acid

Product 1

HCID 11107373Methyl 8-bromooctanoate

Procedure

Under N2 atmosphere, 8-bromooctanoic acid was dissolved in dry methanol. Concentrated H2SO4 was added drop-wise and the reaction mixture was stirred under reflux for three hours.

Workup

temperatureunder reflux for three hours

Sources & evidence

ORD record: ord-321cae9194d44168ab17a7db2f9c927d
Source dataset: uspto-grants-2016_06
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US09365610B2

Reaction notes

Loading…