反应详情

Dissolve 3′-m-tolyl-2,3,5,6-tetrahydro-[1,2′]bipyrazinyl-4-carboxylic acid t-butyl ester (3.3 g, 9.32 mmol) in DCM (10 mL). Add cold (from refrigerator) trifluoroacetic acid (42.6 g, 28.8 mL). Stir for 2 hr. at room temperature. Partition reaction mixture between methylene chloride and 5N NaOH (pH aqueous=14). Separate layers. Extract aqueous layer with methylene chloride (2×20 mL). Combine organic layers, dry over anh. sodium sulfate, filter and concentrate to give the title preparation (2.35 g, 99%). MS (ES): m/z=255 [M+H]+.

1. customat room temperature
2. customPartition
3. customreaction mixture between methylene chloride and 5N NaOH (pH aqueous=14)
4. dry with materialCombine organic layers, dry over anh. sodium sulfate
5. filtrationfilter
6. concentrationconcentrate
7. customto give the title
8. custompreparation (2.35 g, 99%)