Hydrochloric Acid → HCID 67367519, compound

Participants

Reaction Steps

Add 4M HCl in dioxane (8 mL) to a solution of 3′-(2-fluorophenyl)-2,3,5,6-tetrahydro-[1,2′]-bipyrazinyl-4-carboxylic acid t-butyl ester (1.48 g, 4.13 mmol) in 1,4-dioxane (8 mL), and stir the mixture at room temperature for 3 hr. then at 40° C. for 16 hr. Allow the reaction to cool, filter off the precipitated solid, wash with 1,4-dioxane and dry under reduced pressure at 60° C., to give the title preparation as a yellow solid (960 mg, 70%). MS (ES) m/z=259 [M+H].

Provenance & Evidence