Hydrochloric Acid → HCID 67367519, compound

HRID 220420Notes

Reaction equation

HRID 220420 reaction equation
[ClH:1].C(OC([N:9]1[CH2:14][CH2:13][N:12]([C:15]2[C:20]([C:21]3[CH:26]=[CH:25][CH:24]=[CH:23][C:22]=3[F:27])=[N:19][CH:18]=[CH:17][N:16]=2)[CH2:11][CH2:10]1)=O)(C)(C)C>O1CCOCC1>[ClH:1].[ClH:1].[F:27][C:22]1[CH:23]=[CH:24][CH:25]=[CH:26][C:21]=1[C:20]1[C:15]([N:12]2[CH2:11][CH2:10][NH:9][CH2:14][CH2:13]2)=[N:16][CH:17]=[CH:18][N:19]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 68740005HCID 68740005, compound

Product 1

HCID 67367519HCID 67367519, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent2×

Procedure

Add 4M HCl in dioxane (8 mL) to a solution of 3′-(2-fluorophenyl)-2,3,5,6-tetrahydro-[1,2′]-bipyrazinyl-4-carboxylic acid t-butyl ester (1.48 g, 4.13 mmol) in 1,4-dioxane (8 mL), and stir the mixture at room temperature for 3 hr. then at 40° C. for 16 hr. Allow the reaction to cool, filter off the precipitated solid, wash with 1,4-dioxane and dry under reduced pressure at 60° C., to give the title preparation as a yellow solid (960 mg, 70%). MS (ES) m/z=259 [M+H].

Workup

  1. waitthen at 40° C. for 16 hr
  2. customthe reaction
  3. temperatureto cool
  4. filtrationfilter off the precipitated solid
  5. washwash with 1,4-dioxane
  6. customdry under reduced pressure at 60° C.
  7. customto give the title

Sources & evidence

ORD record
ord-a78fdf187fee41099e71b1680ed98b75
Source dataset
uspto-grants-2012_06
Patent number
US08202873B2

Reaction notes

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