HuagongsheHuagongshe Chemistry Print Report · For research reference only
Piperazine → 3'-(4-Methoxyphenyl)-2,3,5,6-tetrahydro-[1,2']bipyrazine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Piperazine | HCID 4837 | — |
| Reactant | 2-Chloro-3-(4-methoxyphenyl)pyrazine | HCID 13199888 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 3'-(4-Methoxyphenyl)-2,3,5,6-tetrahydro-[1,2']bipyrazine | HCID 68595204 | — |
Reaction Steps
Couple 2-chloro-3-(4-methoxyphenyl)-pyrazine (0.236 g, 1.07 mmol) and piperazine (3.10 g, 36.0 mmol) in tetrahydrofuran (5 mL) and heat at 120° C. for 2 hr. Purify using silica gel chromatography, eluting with 0:100 to 20:80 methanol:DCM, to give the title preparation (0.220 g, 76%). MS (ES): m/z=271 [M+H]+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08202873B2 |
| Source dataset | uspto-grants-2012_06 |
| ORD ID | ord-73bf8dc354da456f81a25092e1e260e0 |
| Source note | uspto-grants-2012_06 |