反应详情

Couple 2-chloro-3-(4-methoxyphenyl)-pyrazine (0.236 g, 1.07 mmol) and piperazine (3.10 g, 36.0 mmol) in tetrahydrofuran (5 mL) and heat at 120° C. for 2 hr. Purify using silica gel chromatography, eluting with 0:100 to 20:80 methanol:DCM, to give the title preparation (0.220 g, 76%). MS (ES): m/z=271 [M+H]+.

1. customPurify
2. washeluting with 0:100 to 20:80 methanol
3. customDCM, to give the title
4. custompreparation (0.220 g, 76%)