3-chloro-1-methyl-5-nitropyridin-2(1H)-one → 3-Amino-5-chloro-1-methylpyridin-2(1H)-one

HRID 2204313Notes

Reaction equation

HRID 2204313 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([N+:10]([O-])=O)[C:5](=[O:9])[N:6]([CH3:8])[CH:7]=1.ClC1C(=O)N(C)C=C([N+]([O-])=O)C=1>>[NH2:10][C:4]1[C:5](=[O:9])[N:6]([CH3:8])[CH:7]=[C:2]([Cl:1])[CH:3]=1

Participants

3

Reactant 2

HCID 867031063-chloro-1-methyl-5-nitropyridin-2(1H)-oneHCID 867031195-Chloro-1-methyl-3-nitropyridin-2-one

Product 1

HCID 867031183-Amino-5-chloro-1-methylpyridin-2(1H)-one

Procedure

The title compound was prepared in analogy to the procedure for Step E5, but 5-chloro-1-methyl-3-nitro-1H-pyridin-2-one (Step L5) was used instead of 3-chloro-1-methyl-5-nitro-1H-pyridin-2-one to afford the title compound as a gray solid. ESI-MS: tR=0.54 min, [M+H]+ 159/161 (LC-MS 1).

Sources & evidence

ORD record
ord-ab0fbb5ee20a458590582f8fc50e8f30
Source dataset
uspto-grants-2016_06
Patent number
US09365576B2

Reaction notes

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