HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methylamine → HCID 80859278, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methylamine | HCID 6329 | — |
| Reactant | 5-Bromo-2-chloro-4-methoxypyrimidine | HCID 3663143 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | HCID 80859278 | HCID 80859278 | — |
Reaction Steps
5-Bromo-2-chloro-4-methoxypyrimidine [57054-92-9] (8.68 mmol) and methylamine (2M in THF) (19.54 mmol) in THF (15 mL) were stirred at rt for 32 h and the reaction mixture was concentrated. The residue was purified by flash chromatography to afford the title compound as a white solid. ESI-MS: tR=0.81 min, [M+H]+ 218/220 (LC-MS 2).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09365576B2 |
| Source dataset | uspto-grants-2016_06 |
| ORD ID | ord-6554d6e55be0477f8b82633c204d0b02 |
| Source note | uspto-grants-2016_06 |