Methylamine → HCID 80859278, compound

HRID 2204326Notes

Reaction equation

HRID 2204326 reaction equation
[Br:1][C:2]1[C:3]([O:9][CH3:10])=[N:4][C:5](Cl)=[N:6][CH:7]=1.[CH3:11][NH2:12]>C1COCC1>[Br:1][C:2]1[C:3]([O:9][CH3:10])=[N:4][C:5]([NH:12][CH3:11])=[N:6][CH:7]=1

Participants

4

Reactant 2

HCID 6329MethylamineHCID 36631435-Bromo-2-chloro-4-methoxypyrimidine

Product 1

HCID 80859278HCID 80859278, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

5-Bromo-2-chloro-4-methoxypyrimidine [57054-92-9] (8.68 mmol) and methylamine (2M in THF) (19.54 mmol) in THF (15 mL) were stirred at rt for 32 h and the reaction mixture was concentrated. The residue was purified by flash chromatography to afford the title compound as a white solid. ESI-MS: tR=0.81 min, [M+H]+ 218/220 (LC-MS 2).

Workup

  1. concentrationthe reaction mixture was concentrated
  2. customThe residue was purified by flash chromatography

Sources & evidence

ORD record
ord-6554d6e55be0477f8b82633c204d0b02
Source dataset
uspto-grants-2016_06
Patent number
US09365576B2

Reaction notes

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