反应详情

The title compound was prepared in analogy to the procedure described for Example 17 but 2-bromo-5-(3-chloro-4-fluoro-phenyl)-6-(4-chloro-phenyl)-1-isopropyl-5,6-dihydro-1H-pyrrolo[3,4-b]pyrrol-4-one (Intermediate D) and 2-methoxy-5-[(methylamino)carbonyl]phenylboronic acid (Intermediate R) were used instead of 2-bromo-5-(5-chloro-2-methyl-phenyl)-6-(4-chloro-phenyl)-1-isopropyl-5,6-dihydro-1H-pyrrolo[3,4-b]pyrrol-4-one and 5-cyano-2-methoxyphenylboronic acid respectively. The title compound was obtained as a white solid. tR: 7.27 min (HPLC 2); ESI-MS: tR=1.24 min, [M+H]+ 566/568/570 (LC-MS 1); TLC: Rf=0.07 (98:2 CH2Cl2/MeOH).

1. customThe title compound was prepared in analogy to the procedure