HuagongsheHuagongshe Chemistry Print Report · For research reference only
(5-Cyano-2-Methoxyphenyl)Boronic Acid → HCID 72204596, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (5-Cyano-2-Methoxyphenyl)Boronic Acid | HCID 23005336 | — |
| Reactant | (R)-5-(5-Chloro-2-methyl-phenyl)-6-(4-chloro-phenyl)-2-(2,4-dimethoxy-pyrimidin-5-yl)-1-isopropyl-5,6-dihydro-1H-pyrrolo[3,4-b]pyrrol-4-one | HCID 72206456 | — |
| Reactant | 2-Bromo-5-(3-chloro-4-fluoro-phenyl)-6-(4-chloro-phenyl)-1-isopropyl-5,6-dihydro-1H-pyrrolo[3,4-b]pyrrol-4-one | HCID 86703098 | — |
| Reactant | 2-bromo-5-(5-chloro-2-methyl-phenyl)-6-(4-chloro-phenyl)-1-isopropyl-5,6-dihydro-1H-pyrrolo[3,4-b]pyrrol-4-one | HCID 86703169 | — |
| Product | HCID 72204596 | HCID 72204596 | — |
Reaction Steps
The title compound was prepared in analogy to the procedure described for Example 17 but 2-bromo-5-(3-chloro-4-fluoro-phenyl)-6-(4-chloro-phenyl)-1-isopropyl-5,6-dihydro-1H-pyrrolo[3,4-b]pyrrol-4-one (Intermediate D) and 2-methoxy-5-[(methylamino)carbonyl]phenylboronic acid (Intermediate R) were used instead of 2-bromo-5-(5-chloro-2-methyl-phenyl)-6-(4-chloro-phenyl)-1-isopropyl-5,6-dihydro-1H-pyrrolo[3,4-b]pyrrol-4-one and 5-cyano-2-methoxyphenylboronic acid respectively. The title compound was obtained as a white solid. tR: 7.27 min (HPLC 2); ESI-MS: tR=1.24 min, [M+H]+ 566/568/570 (LC-MS 1); TLC: Rf=0.07 (98:2 CH2Cl2/MeOH).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09365576B2 |
| Source dataset | uspto-grants-2016_06 |
| ORD ID | ord-db27f3c1ba2949cfb55ed8a4e478bca1 |
| Source note | uspto-grants-2016_06 |